Team - Mariana P. Monteiro, M.D., Ph.D.

Mariana P. Monteiro, M.D., Ph.D.

Mariana P. Monteiro, M.D., Ph.D.

General Coordinator, Principal Researcher, Clinical Researcher

ORCIDiD icon0000-0002-0662-1831
email iconmpmonteiro@icbas.up.pt
Current position(s): Principal Investigator, General Coordinator UMIB
Research group: Endocrine and Metabolic Research


Academic degrees
  • PhD in Medical Sciences
  • Medical Doctor – University of Porto
Other positions
  • Director/General Coordinator Unit for Multidisciplinary Research in Biomedicine (UMIB), ICBAS, University of Porto;
  • Associate Professor, ICBAS – University of Porto;
  • Honorary Senior Clinical Lecturer – University College London;
  • Consultant Endocrinology, Hospital Arrábida, Porto.
Research interests
  • To study the role and mechanism of action of gastro-intestinal hormones in energy and glucose homeostasis which can have potential implications in the treatment of type 2 diabetes and obesity.
  • To develop innovative medical and surgical treatments for obesity and type 2 diabetes, through the optimization of bariatric surgery procedures towards improved metabolic outcomes.
  • To study the role of obesity and metabolic syndrome in activating molecular pathways leading to cancer progression in order to identify novel molecular markers for disease diagnosis and treatment targets.
Major Scientific Achievements
  • Scientific advances of her group contributed to maximize the therapeutic benefits of tailored bariatric surgical interventions in obese type 2 diabetic patients.
  • The detailed characterization of the anatomy of the incretin system in the human small intestine was a major breakthrough that allowed to pinpoint how more targeted surgical manipulations of the intestinal anatomy could be used to improve metabolic pathways and patient outcomes.
  • Identified potential targets to induce negative energy balance and improve metabolic disorders by the modulation of gut hormone profile and biological activities through immune blockade of active ghrelin.
  • Earlier research efforts contributed towards the understanding of the role, mechanism of action and potential clinical application of gut hormones in energy homeostasis regulation, including ghrelin, GLP-1, PYY and PP.
Selected publications
  1. Monteiro MP, Batterham RL. The Importance of the Gastrointestinal Tract in Controlling Food Intake and Regulating Energy Balance. Gastroenterology. 2017 May;152(7):1707-1717.e2. doi: 10.1053/j.gastro.2017.01.053)
  2. Nora M, Morais T, Almeida R, Guimarães M, Monteiro MP. Should Roux-en-Y gastric bypass biliopancreatic limb length be tailored to achieve improved diabetes outcomes? Medicine. 2017 Dec;96(48):e8859. doi: 10.1097/MD.0000000000008859.
  3. Guedes TP, Martins S, Costa M, Pereira SS, Morais T, Santos A, Nora M, Monteiro MP. Detailed characterization of incretin cell distribution along the human small intestine. Surg Obes Relat Dis. 2015 Nov-Dec;11(6):1323-31. doi: 10.1016/j.soard.2015.02.011.
  4. Andrade S, Pinho F, Ribeiro AM, Carreira M, Casanueva FF, Roy P, Monteiro MP. Immunization against active ghrelin using virus-like particles for obesity treatment. Curr Pharm Des. 2013;19(36):6551-8.
  5. Jesudason DR, Monteiro MP, McGowan BM, Neary NM, Park AJ, Philippou E, Small CJ, Frost GS, Ghatei MA, Bloom SR. Low-dose pancreatic polypeptide inhibits food intake in man. Br J Nutr. 2007 Mar;97(3):426-9
Ongoing projects

FCT, PTDC/BIM-MET/4712/2014. Obesitility – Gut hormones and testicular metabolism: mechanisms associated with obesity¬-related male infertility. PI: Marco Alves, PhD. Researcher: Mariana Monteiro (15%)

FCT, PTDC/BIM-MET/2123/2014. Novel anti-obesity therapy: melanocortins induction of beige adipocytes. PI: Alexandra Gouveia, PhD. Researcher: Mariana Monteiro (15%)

Concluded projects

FCT, EXPL/BIM-MET/0618/2012. Anti-ghrelin vaccine, a feasible alternative for obesity treatment?
PI: Mariana Monteiro, PhD (35%)

FCT, PTDC/SAU-NMC/115700/2009. The role of the vagus nerve and brainstem pathways in the mechanisms of gastro-intestinal hormones induced weight loss. PI: Mariana Monteiro, PhD (25%)

FCT, PTDC/CVT/122777/2010. Role of the adipose tissue in the host immune response to N. caninum infection. PI: Luzia Teixeira, PhD. Researcher: Mariana Monteiro (15%)

FCT, PTDC/SAU-OSM/68204/2006. Changes in gastro-intestinal hormones after weight loss induced by bariatric surgery with gastric banding. PI: Helena Cardoso, PhD. Researcher: Mariana Monteiro (15%)

FCT, POCI/AMB/61248/2004. Se-induced prevention of Hg toxicity. PI: Artur Águas. Researcher: Mariana Monteiro (15%)

Prizes, honors, awards

2017 Prémio Nacional de Diabetologia, Sociedade Portuguesa de Diabetologia.

2016 Prémio Melhor Comunicação Oral na 50ª Reunião da Sociedade Anatómica Portuguesa / 3ª Reunião Científica da Associação Anatómica Portuguesa, Sociedade Anatómica Portuguesa / Associação Anatómica Portuguesa

2015 1º Prémio para melhor artigo original publicado na revista portuguesa de endocrinologia, diabetes e metabolismo (RPEDM) em 2015 (investigação clínica), Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo

2013 Prémio Manuel Pinheiro Hargreaves no Endocrinology and Metabolism post-graduation course. Hospital S João – Porto (Portugal)

2012 Prémio de Melhor comunicação no 2º Congresso da Associação Luso Galaica de Endocrinologia, Diabetes e Metabolismo. – Porto (Portugal)

2010 Prémio da Melhor Comunicação Oral em Investigação Básica, Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo

2009 Prémio de Investigação Clínica 2009, Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo

2008 Prémio Melhor Comunicação Oral, Sociedade Portuguesa para o estudo da Obesidade

2005 Menção Honrosa de Investigação Clínica, Sociedade Portuguesa de Endocrinologia 2005

2004 Menção Honrosa do Prémio de Casuística 2004, Sociedade Portuguesa de Endocrinologia

2003 Bolsa de Investigação de Curta Duração, Fundação Gulbenkian

2003 Prémio Doutor Ignácio Salcedo 2003, Sociedade Portuguesa para o Estudo da Obesidade

2003 Prémio Caso Clínico, Sociedade Portuguesa de Endocrinologia

2002 Prémio de Epidemiologia 2002, Sociedade Portuguesa de Diabetologia

2002 Prémio de Epidemiologia 2002, Sociedade Portuguesa de Endocrinologia

2002 Menção Honrosa do Prémio de Epidemiologia 2002, Sociedade Portuguesa de Endocrinologia

2001 Prémio Doutor Ignácio Salcedo 2001, Sociedade Portuguesa para o Estudo da Obesidade

International collaborations
  • Jens J. Holst, MD, PhD; University of Copenhagen; Characterization of the hormonal profile of patients submitted to different bariatric surgical procedures.
  • Rachel Batterham, MD, PhD; University College Medical School; Determine if surgical procedure allocation based upon genotype improves post-surgical weight-loss and metabolic outcomes.
  • Miguel Constância, PhD; University of Cambridge; Epigenetic studies of obesity and diabetes.
  • Filipe Casanueva, MD, PhD; Santiago de Compostela University; Regulation of food intake, adipocyte function and overall homeostasis of body weight.
PhD thesis supervision (concluded)
  • Sara Maria Monteiro Sousa Andrade, Endocrinology PhD Program, Different therapeutic approaches to obesity, 2015
  • Marta Filomena Gonçalves de Castro Guimarães, Medical Sciences PhD Program, O bypass gástrico como técnica cirúrgica de eleição no tratamento da obesidade associada à síndrome metabólica e diabetes, 2015
  • Sofia Daniela da Silva Pereira, Biomedical Sciences PhD Program, Adrenocortical tumors: Evaluation of immunohistochemistry markers for their differential diagnosis and of the ERK signaling pathway as a potential target in anti-tumor therapy, 2017
PhD thesis supervision (ongoing)
  • Tiago André Coutinho Morais, Biomedical Sciences PhD Program, Epigenetic insights into the molecular crosstalk of obesity and type 2 diabetes, 2021
  • Ana Paula Santos, Medical Sciences PhD Program, NEUROENDOCRINE TUMOURS AND CHRONIC INFLAMATION: A MODEL FOR THE ASSOCIATION BETWEEN ENDOCRINE FEEDBACK MECHANISMS AND CANCER PATHOGENESIS, 2018
  • Ana Luísa Silva, Biomedical Sciences PhD Program, The Impact of Body Composition on Colorectal Cancer Staging and Prognosis, 2019
  • Silvia Almeida, Medical Sciences PhD Program, Obesidade e doença periodontal, 2018
MSc thesis supervision (concluded)
  • Andreia Ribeiro, Master in Oncology, Cancro da próstata e obesidade: Efeito da leptina na proliferação e angiogénese do cancro da próstata, 2009.
  • Sara Andrade, Master in Molecular genetics, Desenvolvimento de uma vacina anti-ghrelina para tratamento da obesidade, 2010.
  • Maria João Freire, Master degree in Medicine, Efeitos de Bypass Gástrico com Ansa Bilio Pancreática Longa no tratamento de doentes obesos com Diabetes Mellitus Tipo 2, 2010.
  • Sofia Pereira, Master in Oncology, Tumores do córtex da supra-renal: Avaliação do papel dos marcadores imunocitoquimicos em tumores do cortéx da supra – renal, 2012.
  • Tiago Guedes, Master degree in Medicine, Caraterização da distribuição relativa de células neuroendócrinas no jejuno-íleo, 2013.
  • Ângela Moreira, Master in Health Biochemistry, Obesidade e cancro da próstata: Avaliação do efeito dos adipócitos nas células RM1 de carcinoma da próstata, 2013.
  • Filipe Pereira, Master in Oncology, Estudo da densidade linfática nos tumores da tiróide: correlação com a metastização ganglionar,2014.
  • Ana Carvalho, Master degree in Medicine, Défice de Vitamina D e hiperparatiroidismo secundário após cirurgia bariátrica, 2015.
  • Carina Silva, Master in physical activity and health, Efeitos do exercício físico regular no crescimento tumoral induzido por células prostáticas RM1 androgenio-independentes, 2016.
  • Pedro Reis Pereira, Master degree in Medicine, O impacto da cirurgia bariátrica no risco cardiovascular e na prevalência de eventos cardiovasculares em doentes obesos, 2016.
  • Joana Monteiro, Master degree in Medicine, Impacto do Comprimento da Ansa Biliopancreática do Bypass Gástrico na Diabetes Tipo 2, 2016.
  • Rúben Pereira, Master in Oncology, Inflammatory and metabolic molecular markers in neuroendocrine tumors, 2016.
  • António Palha, Master degree in Medicine, Incretin cell distribution at gastro-enteric anastomosis of gastric bypass is variable depending on the biliopancreatic limb length in type 2 diabetics, 2017.
  • Bárbara Patrício, Master in Biochemistry, Comparison of the mixed-meal stimulated gut hormone secretion profile after classical gastric bypass and the long biliopancreatic limb variant, 2017.
  • David Carrageta, Master in Biomedical Sciences, Synthetic xanthine analogues as modulators of adipocytes metabolism, 2017.
  • Raquel Marques, Master degree in Medicine, Nutritional Management of Post-Bariatric Patients, 2018.
  • Carolina Lobato, Master degree in Medicine, Characterization of intestinal hormone dynamics to unravel the anti-diabetic effect of bariatric surgery, 2020.
MSc thesis supervision (ongoing)

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Science and Society
Newspaper articles

Lane, C. (2017, November 21). Simple test predicts diabetes remission following weight loss surgery. UCL. Retrieved from http://www.ucl.ac.uk/news/news-articles/1117/211117-bariatric-surgery-diabetes

Noronha, N. (2016, December 9). Investigadora Portuguesa integra estudo europeu sobre diabetes. Sapo Lifestyle. Retrieved from https://lifestyle.sapo.pt/saude/noticias-saude/artigos/investigadora-portuguesa-integra-estudo-europeu-sobre-a-diabetes

Unknown. (2016, September 23). Prof.ª Doutora Mariana Monteiro sobre a tríade diabetes, obesidade e fertilidade. News Farma. Retrieved from http://www.newsfarma.pt/noticias/4322-prof-%C2%AA-doutora-mariana-monteiro-sobre-a-tr%C3%ADade-diabetes,-obesidade-e-fertilidade.html

Unknown. (2016, April 20). 1.º Simpósio de Diabesidade e Fertilidade em setembro. My Diabetes (News Farma). Retrieved from http://www.mydiabetes.pt/iniciativas/206-1-%C2%BA-simp%C3%B3sio-de-diabesidade-e-fertilidade-em-setembro.html

Unknown. (2016, January 19) UMIB organiza evento para aproximar investigação da indústria farmacêutica. News Farma. Retrieved from http://www.newsfarma.pt/noticias/3399-umib-organiza-evento-para-aproximar-investiga%C3%A7%C3%A3o-da-ind%C3%BAstria-farmac%C3%AAutica.html

Unknown. (2015, July 27). UMIB Summit: Invicta recebe primeiro evento na área da Biomedicina. News Farma. Retrieved from http://www.newsfarma.pt/artigos/2939-umib-submmit-invicta-recebe-primeiro-evento-na-%C3%A1rea-da-biomedicina

Unknown. (2015, June 23). UMIB Summit 2015: reunião multidisciplinar para a investigação translacional. News Farma. Retrieved from http://www.newsfarma.pt/noticias/2816-umib-summit-2015-reuni%C3%A3o-multidisciplinar-para-a-investiga%C3%A7%C3%A3o-translacional.html

Unknown. (2011, July 11). Mariana Monteiro, 39 anos. Correio do Porto. Retrieved from http://www.correiodoporto.pt/do-porto/mariana-monteiro-39-anos

Newspaper articles (authorship)
Monteiro, M. P. (2017, February 8). Multiomics a caminho do tratamento personalizado da diabetes. O futuro?. My Diabetes (News Farma). Retrieved from http://www.mydiabetes.pt/opini%C3%A3o/395-multiomics-a-caminho-do-tratamento-personalizado-da-diabetes-o-futuro.html
Interviews
Monteiro, M. P. (2016, September 23). Interview by News Farma. Prof.ª Doutora Mariana Monteiro sobre a tríade diabetes, obesidade e fertilidade. Retrieved from https://youtu.be/s9R-X9YK004

Monteiro, M. P., Ramos, M. J. (2015, September 28). Interview by University of Porto. Futuro da investigação em biomedicina em debate no ICBAS. Retrieved from https://youtu.be/mqlZhTPd600~

Monteiro, M. P. et al. (2015, April 13). Interview by RTP1, broadcasted by University of Porto. ICBAS faz 40 anos de ensino superior. Retrieved from https://youtu.be/iQ1mPWOcG0w

Monteiro, M. P. (2015, September 17). Interview by News Farma, broadcasted by ViewTV. Prof.ª Doutora Mariana Monteiro: Ponto de situação da diabetes. Retrieved from https://youtu.be/PS9KbnoYFdw

Monteiro, M. P. (2012, June 6). Interview by APDPdiabetes. Mariana Monteiro dá a Cara pela Diabetes. Retrieved from https://youtu.be/8OSKaPgpb8E

TV shows
Monteiro, M. P. Diabetes, Sociedade Civil (RTP 2, 2013): https://www.youtube.com/watch?v=uHtqP0GcXcU
Monteiro, M. P. Diabetes, Praça da Alegria (RTP 1, 2016): http://media.rtp.pt/praca/videos/consultorio-da-praca-diabetes/
Monteiro, M. P. Diabetes, Consultório (Porto Canal, 2017): http://portocanal.sapo.pt/um_video/twW1zbVwFyfIbfdzq8qL/
Monteiro, M. P.. Participação portuguesa no Consorcio Europeu para o Estudo dos Determinantes de Remissão da Diabetes. Mentes que Brilham (Porto Canal, 2017)
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