Endocrine and Metabolic Research

Group leader

Principal Investigator

Team members

Alexandre Seabra, MSc

MSc Student

    Ana Raquel Marques, BSc

    Medical Student

      António M.P. Ribeiro, MD

      Clinical Researcher

        Carolina B. Lobato, MD

        Clinical Researcher

          Emídio Vale-Fernandes, MD

          PhD Student

            Helena Cardoso, MD, PhD

            Integrated PhD Researcher

              J.M. La Fuente, MD, PhD

              Integrated PhD Researcher

                Madalena Santos, BSc

                Laboratory Technician

                  Mário F.C. Nora, MD

                  Clinical Researcher

                    Marta Guimarães, MD, PhD

                    Integrated PhD Researcher

                      Pedro Reis Pereira, MD

                      PhD Student

                        Samuel Cardoso, BSc

                        Media Office Board

                        Medical student

                          Sara Andrade, PhD

                          Integrated PhD Researcher

                            Sofia S. Pereira, Ph.D.

                            Treasurer

                            Integrated PhD Researcher

                              Tiago Morais, Ph.D.

                              Media Office Board

                              PhD student

                                Tiago Pereira Guedes, MD

                                Clinical Researcher

                                  Introduction

                                  The research efforts of the Endocrine and Metabolic Research group have been dedicated to (i) study the role and mechanism of action of gastro-intestinal hormones in energy and glucose homeostasis, (ii) development of innovative medical and surgical treatments for obesity and type 2 diabetes, through the optimization of the surgical techniques used in the clinical setting towards improved outcomes, use of surgical animal models of bariatric surgery and implementation of novel pharmacological approaches for obesity by developing an anti-ghrelin vaccine, (iii) study the role of obesity and metabolic syndrome in prostate cancer progression and the pathways leading to adrenal cancer, since obesity and metabolic syndrome have been recently linked to the increased risk of endocrine related cancer. The Endocrine and Metabolic Research group has established formal research collaborations with several national and laboratories. Research on the role of gastrointestinal in energy homeostasis has been performed in collaboration with the Department of Metabolic Medicine at Imperial College, London. Clinical and translational research on the mechanisms of weight loss and diabetes control after bariatric surgery is being performed by enrolling patients recruited from the Obesity Surgery Outpatient Clinic of Hospital de São Sebastião, Centro Hospitalar de Entre Douro e Vouga, and complemented by the use of rodent models of experimental bariatric surgery, performed at Centro de Cirurgia Experimental Avançada (CCEA) by the same group of surgeons that are responsible for human patients care. The development of an anti-ghrelin vaccine has been performed with the collaboration of Professor Polly Roy, from the Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, UK and Professor Felipe Casanueva from Molecular Endocrinology Department of University Santiago de Compostela, Spain. Research in endocrine related cancer field is being developed in collaboration with Professor Pignatelli from IPATIMUP and Professor Gavin Vinson from Queen Mary, University of London, UK.

                                  Aims

                                  The specific goals of this group area are:
                                  • To study the role and mechanism of action of gastro-intestinal hormones in energy and glucose homeostasis which can have potential implications in the treatment of type 2 diabetes and obesity.
                                  • To develop innovative medical and surgical treatments for obesity and type 2 diabetes, through the optimization of bariatric surgery procedures towards improved metabolic outcomes and pursue the development of pharmacological approaches for obesity treatment with the development of an anti-ghrelin vaccine.
                                  • To study the role of obesity and metabolic syndrome in activating molecular pathways leading to cancer progression in order to identify novel molecular markers for disease diagnosis and treatment targets.

                                  Highlighted publications

                                  1. Pucci A, Tymoszuk U, Cheung WH, Makaronidis JM, Scholes S, Tharakan G, Elkalaawy M, Guimarães M, Nora M, Hashemi M, Jenkinson A, Adamo M, Monteiro MP, Finer N, Batterham RL. Type 2 diabetes remission 2 years post Roux-en-Y gastric bypass and sleeve gastrectomy: the role of the weight loss and comparison of DiaRem and DiaBetter scores. Diabet Med. 2017 Oct 21. doi: 10.1111/dme.13532. doi: 10.1111/dme.13532.
                                  2. Monteiro MP, Batterham RL. The Importance of the Gastrointestinal Tract in Controlling Food Intake and Regulating Energy Balance. Gastroenterology. 2017 May;152(7):1707-1717.e2. doi: 10.1053/j.gastro.2017.01.053
                                  3. Guedes TP, Martins S, Costa M, Pereira SS, Morais T, Santos A, Nora M, Monteiro MP. Detailed characterization of incretin cell distribution along the human small intestine. Surg Obes Relat Dis. 2015 Nov-Dec;11(6):1323-31. doi: 10.1016/j.soard.2015.02.011.
                                  4. Luz A, Santos M, Magalhães R, Oliveira JC, Pacheco A, Silveira J, Cabral S, Torres S, Leite-Moreira AF, Carvalho H. Soluble TNF-related apoptosis induced ligand (sTRAIL) is augmented by Post-Conditioning and correlates to infarct size and left ventricle dysfunction in STEMI patients: a substudy from a randomized clinical trial. Heart Vessels. 2017 Feb;32(2):117-125. doi: 10.1007/s00380-016-0851-9.
                                  5. Patrício BG, Morais T, Guimarães M, Veedfald S, Hartmann B, Hilsted L, Holst JJ, Nora M, Monteiro MP. Gut hormone release after gastric bypass depends on the length of the biliopancreatic limb. Int J Obes (Lond). 2018 May 24. doi: 10.1038/s41366-018-0117-y.

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